History :
- The term "diabetes" was first coined by Araetus of Cappodocia (81-133AD)
- Later, the word mellitus (honey sweet) was added by Thomas Willis (Britain) in 1675 after rediscovering the sweetness of urine and blood of patients (first noticed by the ancient Indians).
- 1776 that Dobson (Britain) firstly confirmed the presence of excess sugar in urine and blood as a cause of their sweetness.
- the concept that diabetes is due to excess glucose production Claude Bernard (France) in 1857
- The role of the pancreas in pathogenesis of diabetes was discovered by Mering and Minkowski (Austria) 1889.
- basis of insulin isolation and clinical use by Banting and Best (Canada) in 1921
- 1955 First OHA Tolbutamide & carbutamide Marketed
Brief :
Diabetes mellitus is a group of metabolic diseases in which a person has high blood sugar, either because the pancreas does not produce enough insulin, or because cells do not respond to the insulin that is produced. This high blood sugar produces the classical symptoms of
-polyuria (frequent urination),
-polydipsia (increased thirst), and
-polyphagia (increased hunger).
Standard Definition:
Diabetes Mellitus is a heterogeneous chronic metabolic disorder principally characterized by persistent hyperglycemia resulting from defects in insulin action and/or insulin secretion.
